Endocrine Abstracts

Sarcoidosis is a multisystem granulomatous disease of unknown cause. The prevalence of neurosarcoidosis is about 5–15%. Hypothalamo-pituitary sarcoidosis is even rarer (<1% of cases evaluated for sellar and stalk lesions).Case Report: A 33-year-old man presented to urology department with erectile dysfunction which started six months ago. Hormonal evaluation revealed gonadotropin deficiency and hyperprolactinemia (Total testosterone: 30.5 ng/dl,...

Introduction: The risk of malignancy has often been reported to be more frequent in Graves’ disease (GD) than non-autoimmune thyroid nodules. However, frequency of thyroid nodules, diagnostic yield of fine-needle aspiration (FNA), and their potential for bearing malignancy in GD are still debatable issues. We aimed to determine the prevalence, ultrasonographic and cytological features, and the rate of malignancy outcome of thyroid nodules in a group of patients with GD.</...

While statins which are used safely to treat dyslipidemia, and improve cardiovascular mortality, recent articles claim that they also impairs glycaemic control in type 2 diabetes patients. Meta-analysis of larger scale studies indicate that use of statins is associated with an increase of 9% in diabetes onset. Despite that, we know not much about their effect on glucose regulation in patients already diagnosed with diabetes. Therefore, we aimed to investigate the effect of sta...

Introduction: Previous reports have shown that subjects with insulin resistance have increased thyroid volume and nodule prevalence. We investigated the effects of metformin on thyroid volume and nodule size.Methods: This prospective data were gathered on newly diagnosed subjects with insulin resistance (n=100, 68 female, 32 male) between August 2008 and May 2010. Measurements of thyroid hormones and thyroid ultrasonography was performed in all ...

Introduction: There is accumulating evidence on the favourable effects of some statins on bone and mineral metabolism. Although some studies have reported drop of serum 25-hydroxyvitamin D levels in subjects receiving statin therapy, comparative studies evaluating various statins in prospective randomized design is lacking. Our purpose is to compare the effects of variable doses of rosuvastatin and atorvastatin on serum 25-hydoxyvitamin D levels adjusted for seasons.<p cla...

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrinopathy that affects 5–10% of women of reproductive age. It is now recognized as not only a reproductive but also a metabolic disorder with co-morbidities, such as; diabetes, dyslipidemia, hypertension, etc. All these metabolic abnormalities predispose women with PCOS to atherosclerosis. Plasma viscosity is a major determinant of blood flow in microcirculation. Preliminary data indicate that elevated plasma...

Objective: The metabolic syndrome (MetS) is a cluster of metabolic abnormalities with insulin resistance (IR) as a major characteristic. It has been recently questioned that MetS and its related components are associated with functional and morphological alterations of thyroid gland. Aim of our study is to examine thyroid volume and nodule prevalence in patients with MetS in a mild-to-moderate iodine deficient area.Design: Two hundred and seventy-eight p...

Objective: Efficacy of eutectic mixture of local anesthetics (EMLA) cream and the needle-free injection of local anesthesia for reducing the pain associated with fine-needle aspiration biopsy (FNAB) of thyroid nodules was previously reported. However, direct comparison of the analgesic efficacy for both methods has not been established yet. The aim of this study was to compare the analgesic efficacy of EMLA cream and needle-free injection of lidocaine for FNAB-associated pain....

Objective: Thyroid hemiagenesis is a rare form of thyroid dysgenesis, in which one thyroid lobe fails to develop. The true prevalence of this rare abnormality is about 0.05–0.2% in normal population. We aimed to determine prevalence of thyroid hemiagenesis in patients with various thyroid disorders and a normal population in a mild to moderate iodine-deficient area.Subjects and methods: The clinical and thyroid ultrasonography records of 4.833 patie...

Objective: Morphologic and functional platelet abnormalities have been previously reported in patients with type 2 diabetes mellitus (DM) and some of these abnormalities have been linked to increased cardiovascular risk. Mean platelet volume (MPV) informs not only about platelet size, but also about its functions. Larger platelets bear more thrombotic potential. Higher MPV values have been correlated with cardiovascular events in the short and long run. Previous studies have d...